UNDER REVIEW (September 2016)

Mechanism of Action:

A sodium channel block blocker (Class 1b). Has its major effect on electrically excitable tissues such as cardiac cells and nervous tissues.

  1. Anti-arrhythmic action – reduces the rate of depolarization of cardiac action potential, increases effective refractory period and decreases atrioventricular conduction.
  2. Local anaesthetic effect. Reduces conduction in sensory neurones.

Lecture and CAL materials: