Metoclopramide

UNDER REVIEW (September 2016)

Mechanism of Action:

Metoclopramide is a dopamine D2 receptor antagonist in the central nervous system. This action interferes with the central mechanisms that create the sensation of nausea and also stimulates lower oesophageal sphincter contraction and gastric motility. These pharmacological effects make metoclopramide a useful drug in nausea/vomiting and gatric motility disorders.

Lecture and CAL materials:

Prochlorperazine

UNDER REVIEW (September 2016)

Mechanism of Action:

A member of the phenothiazine group of “typical” antipsychotic drugs. Predominant action is as a dopamine D2-receptor antagonist which provides a centrally mediated anti-emetic effect.