L- dopa

UNDER REVIEW (September 2016)

Mechanism of Action:

Dopamine, a neurotransmitter, does not cross the blood-brain barrier, and therefore is not useful for therapeutic purposes in Parkinson’s disease. Its precursor, levodopa, can cross the blood-brain barrier, by an amino acid transport mechanism. It is then decarboxylated to active dopamine by dopa decarboxylase in surviving nigrostriatal neurones or other monaminergic nerves, thereby restoring dopaminergic neurotransmission.

Lecture and CAL materials: