Fluoxetine

UNDER REVIEW (September 2016)

Mechanism of Action:

SSRI (selective serotonin reuptake inhibitor); inhibits the reuptake of 5-HT (serotonin) moreso than noradrenaline (norepinephrine) in CNS and peripheral nervous system. Increases the activity of the relevant transmitter(s) – 5-HT (and noradrenaline). Overall effect is anxiolytic, antidepressant, which takes several weeks to develop.

Lecture and CAL materials:

Amitriptyline

UNDER REVIEW (April 2017)

Mechanism of Action:

Amitriptyline is an antidepressant drug from the tricyclic antidepressant group. Amitriptyline probably exerts its antidepressant effects by inhibiting both serotonin and noradrenaline reuptake. It also has analgesic properties which might relate to blocking of calcium channels in the pain pathway (ie non-antidepressant action).

Lecture and CAL materials: