Fludrocortisone

UNDER REVIEW (September 2016)

Mechanism of Action:

A synthetic mineralocorticoid (a type of corticosteroid, the other being glucocorticoids). Mimics the action of aldosterone on mineralocorticoid receptors in kidney tubules to retain sodium and water (raise extracellular fluid volume and subsequently blood pressure) and stimulates potassium excretion.

Lecture and CAL materials:

Hydrocortisone

UNDER REVIEW (September 2016)

Mechanism of Action:

Short-acting synthetic form of the natural glucocorticoid cortisol. Glucocorticoids exert their actions by binding and activating cytoplasmic steroid receptors. Together, they move to the nucleus, causing increased or decreased transcription of genes leading, for example, to increased anti-inflammatory proteins and decreased osteoblast activity. Although hydrocortisone has glucocorticoid activity it has only weak mineralocorticoid (aldosterone-like) activity.

Lecture and CAL materials: