Domperidone

UNDER REVIEW (September 2016)

Mechanism of Action:

Dopamine D2 receptor antagonist.

Lecture and CAL materials:

Hyoscine

UNDER REVIEW (September 2016)

Mechanism of Action:

Peripherally acting muscarinic receptor antagonist (antimuscarinic) that competitively inhibits the action of acetylcholine (ACh) at muscarinic receptors. Muscarinic AChRs are seven-transmembrane G-protein-coupled receptors which are activated by the endogenous neurotransmitter, ACh. They are generally associated with the parasympathetic nervous system, and also cholinergic transmission in the CNS. Hence, antimuscarinics block the effects of parasympathetic nerve stimulation and so dilate pupils, reduce intestinal motility and smooth muscle contraction and reduce secretions from glands (sweat, salivary, bronchial).

Lecture and CAL materials:

Metoclopramide

UNDER REVIEW (September 2016)

Mechanism of Action:

Metoclopramide is a dopamine D2 receptor antagonist in the central nervous system. This action interferes with the central mechanisms that create the sensation of nausea and also stimulates lower oesophageal sphincter contraction and gastric motility. These pharmacological effects make metoclopramide a useful drug in nausea/vomiting and gatric motility disorders.

Lecture and CAL materials: