Clotrimazole

Indications:

  • Cutaneous Candidiasis (Thrush) and other cutaneous fungal (‘dermatophyte’) infections including athlete’s foot.

Mechanism of Action:

Clotrimazole is an antifungal drug (imidazole) that damages the fungal cell wall and alters the permeability. It also inhibits the activity of intracellular enzymes, leading to a buildup of toxic concentrations of hydrogen peroxide within the fungal cell, causing death of the cell. It is used topically; systemic absorption is minimal.

Lecture and CAL materials: (under review)