Mechanism of Action:
Methotrexate is classified as an antimetabolite drug. It blocks DNA synthesis in proliferating cells by binding with and blocking the action of dihydrofolate reductase which enables regeneration of folate, a cofactor in the production of substrates for DNA and RNA synthesis. By this mechanism it prevents cell proliferation making it both immunosuppressant and cytotoxic.
Lecture and CAL materials:
- Lecture: Drugs for IBD, Diarrhoea, Constipation and Motility Disorders
- Lecture: Disease-Modifying Anti-Rheumatic Drugs (DMARDs)
- Lecture: Pain and Analgesia (Lecture 3): Anti-inflammatory Drugs
- Lecture: Introduction to the Treatment of Cancer
- CAL: Pharmacology of Inflammation