Allopurinol

UNDER REVIEW (April 2017)

Mechanism of Action:

Allopurinol inhibits xanthine oxidase, an enzyme involved in the production of uric acid from xanthine and hypoxanthine (purine degradation products). Uric acid is sparingly soluble and, in high concentration can precipitate into crystals. This can cause the extremely painful joint condition known as gout. Allopurinol is an analog of the natural purines in the body, and is quickly metabolised to oxipurinol which is also a xanthine oxidase inhibitor.